Bio-Identical Hormone Replacement Therapy

Bio-identical hormones are hormones that are virtually identical to those produced by your own body. By contrast, synthetic hormones are manufactured by pharmaceutical companies and are chemically similar to (but NOT the same as) the hormones made by your body.

Synthetic hormones may offer a few benefits, but unlike natural hormones, they do NOT always fit exactly into your body's hormone receptor sites.  For this reason they may not work as well as bio-identical hormones and typically have a greater number of undesirable side effects. 

Bio-idendtical Hormone Replacement Therapy (BHRT) is useful in treating women in MENOPAUSE, peri-menopause (beginning menopause), or post-menopause who want to reduce hot flashes, night sweats, and improve the quality of their sleep. BHRT has also been shown to be helpful in improving mood, concentration, and memory, as well as libido.  Women who are on a BHRT program also experience a lower incidence of osteoporosis and are able to maintain better muscle mass and strength which are key components to successful long-term weight management.

BHRT can also be useful in treating men who are suffering from symptoms associated with ANDROPAUSE (the male equivalent of menopause). Typical symptoms include low testosterone, chronic fatigue, loss of libido, erectile dysfunction (ED), irritability, depression, and reduced muscle mass and strength.

Servicing southern Arizona (greater Tucson, Green Valley, Vail, Sahuarita, and Sierra Vista), we take great pride in our ability to prescribe personalized bio-identical hormone therapy (BHRT) “regimens,” including sub-lingual troches and hormone pellet implants that are uniquely tailored to meet our patients’ individual needs. 

After a detailed review of your personal history, together with your laboratory and physical exam results, we can design a BHRT regimen that is just right for you to optimize YOUR hormonal balance. We then carefully monitor and modify (fine tune) your regimen over time, as your needs change.

We take great pride in our ability to prescribe personalized bio-identical hormone BHRT “regimens,” including sub-lingual "troches" and hormone pellet implants (see below), that are uniquely tailored to meet our patients’ individual needs. After a detailed review of your personal history, together with your laboratory and physical exam results, we can design an BHRT regimen that is just right for you to optimize YOUR hormonal balance. We then carefully monitor and modify (fine tune) your regimen over time, as your needs change.

Discover the Benefits of Personalized Bio-Identical Hormones

Hormone Pellet Implants


Data supports that testosterone implants effectively treat symptoms in both men and women. Implants, placed under the skin, consistently release small, physiologic doses of hormones providing optimal therapy without adverse effects.

What are Pellets?

Pellets, or implants are made up of hormones (i.e. testosterone) that are pressed or fused into very small solid cylinders. These pellets are larger than a grain of rice and smaller than a ‘Tic Tac'. In the United States, the majority of pellets are made by compounding pharmacists and delivered in sterile glass vials. There is an 'FDA approved' 75 mg testosterone pellet.  

Why pellets?  

Pellets deliver consistent, healthy levels of hormones for 3-4 months in women and 4-5 months in men. They avoid the fluctuations, or ups and downs, of hormone levels seen with every other method of delivery. This is important for optimal health and disease prevention. Pellets do not increase the risk of blood clots like conventional or synthetic hormone replacement therapy.

In studies, when compared to conventional hormone replacement therapy, pellets have been shown to be superior for relief of menopausal symptoms, maintenance of bone density, restoration of sleep patterns, and improvement in sex drive, libido, sexual response and performance.

Testosterone delivered by a pellet implant, has been used to treat migraine and menstrual headaches. It also helps with vaginal dryness, incontinence, urinary urgency and frequency. In both men and women, testosterone has been shown to increase energy, relieve depression, increase sense of well being, relieve anxiety and improve memory and concentration. Testosterone, delivered by pellet implant, increases lean body mass (muscle strength, bone density) and decreases fat mass. Men and women need adequate levels of testosterone for optimal mental and physical health and for the prevention of chronic illnesses like Alzheimer's and Parkinson's disease, which are associated with low testosterone levels.

Even patients who have failed other types of hormone therapy have a very high success rate with pellets. There is no other ‘method of hormone delivery' that is as convenient for the patient as the implants. Implants have been used in both men and women since the late 1930's. There is significant data that supports the use of testosterone implants in both men and women.

How and where are pellets inserted?

The insertion of pellets is a simple, relatively painless procedure done under local anesthesia. The pellets are usually inserted in the lower abdominal wall or upper buttocks through a small incision, which is then closed with a skin tape (steri-strip). The experience of the health care professional matters a great deal, not only in placing the pellets, but also in determining the correct dosage of hormones to be used.

Are there any side effects or complications from the insertion of the pellets?

Complications from the insertion of pellets include; minor bleeding or bruising, discoloration of the skin, infection, and the possible extrusion of the pellet. Other than slight bruising, or discoloration of the skin, these complications are rare.

Testosterone may cause a slight increase in facial hair in some women. Testosterone stimulates the bone marrow and increases the production of red blood cells. A low testosterone level in older men is a cause of anemia. Testosterone, delivered by implants or other methods, can cause an elevation in the red blood cells. If the hemoglobin and hematocrit (blood count) get too high, a unit of blood may be donated.

After the insertion of the implants, vigorous physical activity is avoided for 48 hours in women and up to 5 to 7 days in men. Early physical activity is a cause of ‘extrusion', which is a pellet working it's way out. Antibiotics may be prescribed if a patient is diabetic or has had a joint replaced. However, this is a ‘clean procedure' and antibiotics may not be needed.

Why haven't I heard about Pellets?

You may wonder why you haven't heard of pellets. Pellets are not patented and have not been marketed in the United States. They are frequently used in Europe and Australia where pharmaceutical companies produce pellets. Most of the research on pellets is out of Europe and Australia. Pellets were frequently used in the United States from about 1940 through the late 70's when oral patented estrogens were marketed to the public. In fact, some of the most exciting data on hormone implants in breast cancer patients is out of the United States. Even in United States, there are clinics that specialize in the use of pellet implants for hormone therapy.

Do men need hormone therapy?

Testosterone levels begin to decline in men beginning in their early 30's. Most men maintain adequate levels of testosterone into their mid 40's to mid 50's, some into their late 70's to early 80's. Men should be tested when they begin to show signs of testosterone deficiency. Even men in their 30's can be testosterone deficient and show signs of bone loss, fatigue, depression, erectile dysfunction, difficulty sleeping and mental decline. Most men need to be tested around 50 years of age. It is never too late to benefit from hormone therapy.

What if my primary care physician or my gynecologist says that there is ‘no data' to support the use of pellet implants?

He or she is wrong. There is a big difference between ‘no data' and not having read the data. It is much easier for busy practitioners to dismiss the patient, than it is to question their beliefs and do the research. It's about a patient making an informed choice. After testosterone pellets are inserted, patients may notice that they have more energy, sleep better and feel happier. Muscle mass and bone density will increase while fatty tissue decreases. Patients may notice increased strength, co-ordination and physical performance. They may see an improvement in skin tone and hair texture. Concentration and memory may improve as will overall physical and sexual health. There is also data to support the ‘long term' safety of testosterone delivered by pellet implants.

Do testosterone implants have the same danger of breast cancer as other forms of hormone replacement therapy?

Testosterone, delivered by pellet implantation, has been shown to decrease breast proliferation and lower the risk of breast cancer, even in patients on conventional hormone replacement therapy. Clinical studies show that testosterone balances estrogen and is breast protective. In the past, testosterone implants have been used to treat patients with advanced breast cancer. In 1940, it was theorized that treating patients with testosterone implants earlier, at the time of diagnosis, would have an even greater benefit, preventing recurrent disease. Androgens have also been shown to enhance the effect of Tamoxifen® therapy in breast cancer patients.

In contrast to testosterone, Estradiol, whether delivered by pellet implant*, applied topically to the skin or taken orally has been shown to increase the risk of breast cancer.  This is not surprising, as continuous Estradiol, a strong estrogen, has been shown to stimulate breast tissue.

* Million Women’s Study

Are there other hormones besides testosterone that have not been shown to increase the risk of breast cancer?

Bio-identical progesterone (including FDA approved Prometrium®) has not been shown to increase the risk of breast cancer like the synthetic progestins. In addition, progesterone, used vaginally, does not negate the beneficial effects of estrogen on the heart like the synthetic progestins.

Estriol is a bio-identical estrogen widely used in Europe that does not bind strongly to estrogen receptor and does not stimulate breast tissue. Numerous studies have shown that vaginal estriol does not increase the risk of breast cancer (RR 0.7). It has safely been used in breast cancer survivors.  However, higher doses of vaginal estradiol (> 25 mcg) and vaginal Premarin® provide systemic levels of strong estrogens that may stimulate breast tissue.  If you are a breast cancer survivor, it is important that your physician understands this.   Balanced hormones are the key to health and disease prevention.

Why isn’t estrogen therapy or Estradiol pellet therapy recommended?

Approximately 50% of women who are treated with estrogen (especially the pellet implant) will experience uterine bleeding.  If a menopausal patient has bleeding, she must notify her gynecologist or family physician and have an evaluation, which may include a vaginal ultrasound and endometrial biopsy.  The primary cause of bleeding is stimulation of the uterus by estrogen.  Estrogen also stimulates the breast tissue can cause breast pain and cysts.  It also increases the risk of breast cancer.  Higher levels of estrogen (in the second half of the menstrual cycle) are needed for pregnancy.  Most women feel better with lower levels of estrogen.We have shown that symptoms, including hot flashes, are relieved with continuous testosterone alone.  Testosterone delivered by pellet implant is extremely effective therapy.   In addition, it does not have the unwanted side effects of estrogen therapy.

  • Almost all symptoms, including hot flashes, are relieved with testosterone pellets alone. A study by Sherwin in 1985 looked at testosterone, testosterone with estradiol, estradiol alone and placebo. The group of women who responded best (somatic, psychological and total score)…testosterone alone! The groups that did the worst…estrogen alone and placebo. Higher levels of testosterone were associated with a better response. These results are expected.Testosterone,not circulating estradiol, is the major ‘substrate’ for estrogen production in the brain, bones, vascular system, breast and adipose tissue. Some physicians do not understand this and may insist that estrogen therapy is needed.  
  •  Most patients treated with testosterone implants choose not to use estradiol (stronger estrogen). Excess estrogen can cause anxiety, weight gain, belly fat, tender breasts, emotional lability, symptoms of PMS, and mood swings. Long-term exposure to stronger estrogens like estradiol and Premarin can increase the risk of breast cancer. In addition, there is exposure to many estrogen-like chemicals.
  •  Some women (and men) ‘aromatize’ or convert too much testosterone to estradiol, which can interfere with the beneficial effects of testosterone. An ‘aromatase inhibitor’ (i.e. anastrozole) may be prescribed to prevent this. Patients, including breast cancer survivors, may be treated with the combination testosterone-anastrozole implants.
  • If needed, one of the most effective and safest ways to deliver estrogen is vaginally as a cream or tablet (Vagifem®). This treats vaginal symptoms like dryness and discomfort, along with urinary symptoms like urgency, frequency, hesitancy, nocturia (waking at night to urinate) and incontinence. Estriol (E3) is less stimulatory to the breast tissue and uterus than estradiol and may be combined with progesterone in a single cream. The vaginal cream may be used daily for 14 days, then 2 to 6 days per week as needed. Once tissue is healed and symptoms are no longer present, the vaginal cream or tablet may be discontinued.
  • Testosterone increases muscle mass and bone density while decreasing fatty tissue. However, a diet of refined carbohydrates/sugars will prevent weight loss and other benefits of testosterone implant therapy. Diet and lifestyle (exercise) are extremely important for health and well-being.  Prescription medications can also interfere with the effect of the testosterone implant. For additional information, see the ‘Trouble Shooting’ handout.

  • Progesterone may be used in addition to testosterone to help women who have difficulty with sleep, hot flashes, tension or anxiety. Testosterone and progesterone have beneficial effects on the brain and nervous system.

Will hormone therapy with estradiol and testosterone pellets help with hair loss?

Hormone deficiency is a common cause of hair loss and treatment with estradiol and testosterone implants can help to re-grow hair. Hair becomes thicker and less dry with pellet therapy.

How long until a patient feels better after pellets are inserted?

Some patients begin to ‘feel better' within 24-48 hours while others may take a week or two to notice a difference. Diet and lifestyle, along with hormone balance are critical for optimal health. Stress is a major contributor to hormone imbalance and illness.  Side effects and adverse drug events from prescription medications can interfere with the beneficial effects of the testosterone implant.

How long do pellets last?

The pellets usually last between 3-4 months in women and 4-5 months in men. The pellets do not need to be removed. They completely dissolve on their own.

Do patients need progesterone when they use the pellets?

Women who are treated with testosterone implants alone (no estrogen therapy) do not require progestin therapy.  However, if estradiol, or other estrogen therapy is prescribed, progestins are also needed. The main indication for the use of synthetic progestins, like Provera® or progesterone, is to prevent the proliferation (stimulation) of the uterine lining caused by estrogen.  Progestin therapy is NOT required if estrogen therapy is not prescribed.  However, there may be health benefits to progesterone.

How are hormones monitored during therapy?

Hormone levels may be drawn and evaluated before therapy is started. This may include an FSH, estradiol, testosterone (free and total) for women. Men need a PSA (prostate specific antigen), sensitive estradiol, testosterone, LH, liver profile and blood count prior to starting therapy. Thyroid hormone levels (TSH) may also be evaluated.

In men, follow up levels, including a PSA, blood count and estradiol, may be obtained prior to subsequent testosterone implantation. Men must notify their primary care physician and obtain a digital rectal exam each year. Women are advised to continue their monthly self-breast exam and obtain a mammogram and/or pap smear as advised by their gynecologist or primary care physician.

How much does this cost?

The cost for the insertion of pellets is between $300 and $800 depending on the dose of the hormone and the number of pellets needed. Men need a much larger dose of testosterone than women and the cost is higher. Pellets need to be inserted 2 to 4 times a year depending on how rapidly a patient metabolizes hormones.  When compared to the cost of drugs to treat the individual symptoms of hormone decline, pellets are very cost effective.

Is there a role for testosterone implants (pellets) in a pre-menopausal female?

Testosterone pellets may be used in pre-menopausal females (women who have not stopped menstruating). Testosterone has been shown to relieve migraine or menstrual headaches, help with symptoms of PMS (pre menstrual syndrome), relieve anxiety and depression, increase energy, help with sleep and improve sex drive and libido. If a pre-menopausal female has a testosterone pellet inserted, she must use birth control. There is a theoretical risk of ‘masculinizing’ a female fetus (giving male traits to a female fetus).

Can a patient be allergic to the implants?

Very rarely, a patient will develop local zone of redness (3-8 cm) and itching at the site of the testosterone implant.  There is minimal or no tenderness and no other sign of infection. Pellets are made of up testosterone, stearic acid and PVP (povidone).  Patients may react to the PVP.  Implants can be compounded or made without PVP.  Many patients who develop a local reaction to the implant have low cortisol levels and upon further questioning, have symptoms of adrenal insufficiency.  Cortisol testing may be recommended. If needed, 25-50 mg of benedryl works well for the itching.

In conclusion, testosterone therapy by implantation of pellets is a safe and effective method of hormone therapy for both men and women. Continuous administration of hormones by pellets is convenient and economical for the patient. Pellet implantation has consistently proven more effective than oral, intramuscular, and topical hormone therapy with regard to bone density, sexual function, mood and cognitive function, urinary and vaginal complaints, breast health, lipid profiles, hormone ratios and metabolites.




For current fee schedule, please call our office.  Payment is required at the time of your appointment. Except for lab work (which is generally covered by insurance) we do NOT accept insurance for bio-identical hormone replacement therapy appointments.  The initial visit will take approximately an hour.  After your hormones have been properly balanced, we will ask that you come in for a follow-up visit at least once every six months for on-going monitoring and evaluation


The views expressed above on the benefits of bio-identical hormone replacement therapy, and hormone replacement therapy in general, are those of Dr. Genifer Y. Chavez MD MPH, and in no way represent or imply her endorsement of the use of such therapies without the proper care and supervision provided by a qualified prescribing physician.

For Bio-Identical Hormone Replacement in Tucson, Contact Us:

To make an appointment call (520) 296-0635

If you have any questions,
comments, or scheduling inquiries,
please call us directly. 

Balanced Health and Wellness, PLC

5930 E Pima St., Suite 124, Tucson, AZ 85712

Phone: (520) 296-0635
Fax: (520) 722-7524


Tuesdays and Fridays: 9 a.m. - 5 p.m. by appointment only